{"id":2053,"date":"2020-07-26T10:54:26","date_gmt":"2020-07-26T10:54:26","guid":{"rendered":"https:\/\/ayurvedanetworkbhu.com\/?p=2053"},"modified":"2022-02-23T07:31:11","modified_gmt":"2022-02-23T07:31:11","slug":"ayurveda-and-drug-re-purposing-by-dr-prashant-gupta","status":"publish","type":"post","link":"https:\/\/ayurvedanetworkbhu.com\/?p=2053","title":{"rendered":"Module on &#8220;Ayurveda and Drug Re-purposing&#8221; by Dr. Prashant Gupta"},"content":{"rendered":"<p><iframe loading=\"lazy\" src=\"https:\/\/www.youtube.com\/embed\/LajhhvQju-A\" width=\"560\" height=\"315\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong>Understanding of Drug repurposing in Ayurveda<\/strong><\/p>\n<p><strong>Content\u00a0<\/strong><\/p>\n<p>In past decade, it is felt that drug discovery is time consuming (large gestation) and an uncertain million dollar affair. The process from a compound to drug almost take 15 years and at least 2 billion dollars are required to transform a compound in to a drug. Denovo drug delivery process has a high attrition rate precisely in a 1 million screened compounds only I reaches to clinical uses showing tract attrition.<\/p>\n<p>Now, a clinical phases faces significant ethical issues and stricter norms, intact getting regulatory clearance from the central govt or state Govts is difficult. It is a marathon.<\/p>\n<p>Hence considering all this scientist are now moving to more pragmatic approach for drug discovery and they are &#8211;<\/p>\n<ul>\n<li>Drug repurposing<\/li>\n<li>Reverse pharmacology<\/li>\n<\/ul>\n<p>Today , we will only discuss drug repurposing<\/p>\n<p><strong>Definitions &#8211;<\/strong><\/p>\n<p>Drug repurposing &#8211; Identifying , developing and commercialising new uses for existing or abandon drug. Eg. Hydroxychloroquine<\/p>\n<p>Drug Repositioning &#8211; Finding new uses outside the scope of original medical indication for existing drug.<\/p>\n<p>Drug Reprofiling &#8211; Reducing the risk and cost associated with drug development with the advantage that the drug has already undergone a pre clinic and clinical testing. Eg. Thelidomide uses for Nausea in 1950s and for Leprosy in 1980s.<\/p>\n<p>Drug Rediscovery &#8211; Investigating new uses for currently prescribed drugs.<\/p>\n<p>Drug reformulation &#8211; Finding ways to modify a formulation to allow a drug to enter a new market\/therapeutics. Eg. Triphala and Balachaturbhadra.<\/p>\n<p>Therapeutic Switching &#8211; Opening up a new possibility for a old medicine that were not appreciated at the time of original discovery and can be therapeutically different through new formulations.<\/p>\n<p>Indication Switching &#8211; Exploiting established drugs that have already been approved for treatment.<\/p>\n<p><strong>Need of the repurposing &#8211;<\/strong><\/p>\n<p>&#8211; Gestational time of de novo drug discovery<\/p>\n<ul>\n<li>Success Rate<\/li>\n<li>Cost<\/li>\n<li>Data Availability<\/li>\n<\/ul>\n<p><strong>How Drug Repurposing is designed &#8211;<\/strong><\/p>\n<ul>\n<li>Machine Learning<\/li>\n<li>Network Analysis<\/li>\n<li>Analysis of omic data<\/li>\n<\/ul>\n<p>Let us discuss the few points regarding drug repurposing<\/p>\n<ul>\n<li><strong>Drug-Drug Similarity<\/strong> \u2014 Chemical Structure, targets, side effect, gene ontology<\/li>\n<li><strong>Disease-Disease Similarity <\/strong>\u2014 Phenotype , Human phenotype ontology, gene ontology.<\/li>\n<\/ul>\n<p>Indian traditional Medicine was a geographically influenced\/dominated health management system of south east Asia. Time to time it incorporated\/ adopted the prevailing science of era for health management viz. Herbominerals\u00a0 and metal bhasmas during renaissance of alchemy proving its development has spatiotemporal contribution.<\/p>\n<p>Ayurveda concepts of repurposing , therapeutic switching, new indication, drug reprofiling, therapeutic potentiation or near terms may be seen scattered in classics.<\/p>\n<p><strong>Why it was need during ancient time &#8211;<\/strong><\/p>\n<ul>\n<li>Geographical limitations of drug availability.<\/li>\n<li>Seasonal Limitation<\/li>\n<li>Environmentally very concerned<\/li>\n<li>Storage and transport<\/li>\n<\/ul>\n<p><strong>Ancient Tricks of Drug Repurposing &#8211;<\/strong><\/p>\n<ul>\n<li>Anupaan<\/li>\n<li>Yukti<\/li>\n<li>Kalpana<\/li>\n<li>Bhavana<\/li>\n<li>Sewan Kaal<\/li>\n<li>Maatra<\/li>\n<\/ul>\n<p>These six tricks (which I thought) were traditional repurposing techniques for utilising the available drugs to the disease prevailing.<\/p>\n<p><strong>Three types of Treatment in Ayurveda <\/strong><\/p>\n<ul>\n<li>Dosha pratyanik<\/li>\n<li>Vyadhi Pratyanik<\/li>\n<li>Ubhaya pratyanika<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Questions:<\/strong><\/p>\n<ol>\n<li>Give two examples of Anupana which change the indication of used drug.<\/li>\n<li>Give example of some other drug which is indicated in different diseases at different doses.<\/li>\n<li>Give two other examples of Bhavana.<\/li>\n<li>Which of the following is not the prophylactic\/therapeutic indication of Hydrocholoroquinone\n<ol>\n<li>Malaria<\/li>\n<li>Rheumatoid arthritis<\/li>\n<li>Covid-19<\/li>\n<li>None<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<ol>\n<li>What do you understand about gene ontology?<\/li>\n<li>What was the thought behind the pious collection of drugs in ancient time?<\/li>\n<li>Write two methods to reduce the cost of drug development research.<\/li>\n<li>Which of the following is the treatment method described in Ayurveda\n<ol>\n<li>Dosha pratyanika chikitsa<\/li>\n<li>Vyadhi pratyanika chikitsa<\/li>\n<li>Ubhya pratyanika chikitsa<\/li>\n<li>All of above<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<ul>\n<li style=\"list-style-type: none;\"><\/li>\n<\/ul>\n<ol>\n<li>Write two more traditional techniques of drug repurposing.<\/li>\n<li>Ayurvedic drugs act through which of the following principle\n<ol>\n<li>Rasa &amp; guna<\/li>\n<li>Virya &amp; vipaka<\/li>\n<li>Prabhava<\/li>\n<li>All of above<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>For further reading:<\/strong><\/p>\n<p>Acharya Priyavrat Sharma, Dravyaguna vigyan part I &amp; II<\/p>\n<p>Charak Samhita, purvardha &amp; Utarardha<\/p>\n<p>Sharangdhar Samhita, Madhyam Khand.<\/p>\n<p>Bhav Prakash Nighantu<\/p>\n<p>Drug repurposing ; a promising tool to accelerate the drug discovery process; drug discovery today; vol. 24 (10)\u00a0 <a href=\"https:\/\/doi.org\/10.1016\/j.drudis.2019.06.014\">https:\/\/doi.org\/10.1016\/j.drudis.2019.06.014<\/a><\/p>\n<p>An update on drug repurposing: rewritten saga of the drugs fate; Biomedicine and pharmacotherapy; Vol 110; <a href=\"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.127\">https:\/\/doi.org\/10.1016\/j.biopha.2018.11.127<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Understanding of Drug repurposing in Ayurveda Content\u00a0 In past decade, it is felt that drug discovery is time consuming (large gestation) and an uncertain million dollar affair. The process from a compound to drug almost take 15 years and at least 2 billion dollars are required to transform a compound in to a drug. [&hellip;]<\/p>\n","protected":false},"author":20,"featured_media":3281,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[116,113,33,55,54],"tags":[],"class_list":["post-2053","post","type-post","status-publish","format-video","has-post-thumbnail","hentry","category-complete-module","category-dr-prashant-kumar-gupta","category-kaumarabhritya-bala-roga","category-text","category-videos","post_format-post-format-video"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"Understanding of Drug repurposing in Ayurveda Content In past decade, it is felt that drug discovery is time consuming (large gestation) and an uncertain million dollar affair. 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The process from a compound to drug almost take 15 years and at least 2 billion dollars are required to transform a compound in to a drug."},"aioseo_meta_data":{"post_id":"2053","title":null,"description":null,"keywords":null,"keyphrases":null,"primary_term":null,"canonical_url":null,"og_title":null,"og_description":null,"og_object_type":"default","og_image_type":"default","og_image_url":null,"og_image_width":null,"og_image_height":null,"og_image_custom_url":null,"og_image_custom_fields":null,"og_video":null,"og_custom_url":null,"og_article_section":null,"og_article_tags":null,"twitter_use_og":false,"twitter_card":"default","twitter_image_type":"default","twitter_image_url":null,"twitter_image_custom_url":null,"twitter_image_custom_fields":null,"twitter_title":null,"twitter_description":null,"schema":{"blockGraphs":[],"customGraphs":[],"default":{"data":{"Article":[],"Course":[],"Dataset":[],"FAQPage":[],"Movie":[],"Person":[],"Product":[],"ProductReview":[],"Car":[],"Recipe":[],"Service":[],"SoftwareApplication":[],"WebPage":[]},"graphName":"","isEnabled":true},"graphs":[]},"schema_type":"default","schema_type_options":null,"pillar_content":false,"robots_default":true,"robots_noindex":false,"robots_noarchive":false,"robots_nosnippet":false,"robots_nofollow":false,"robots_noimageindex":false,"robots_noodp":false,"robots_notranslate":false,"robots_max_snippet":null,"robots_max_videopreview":null,"robots_max_imagepreview":"large","priority":null,"frequency":null,"local_seo":null,"breadcrumb_settings":null,"limit_modified_date":false,"ai":null,"created":"2025-06-06 19:37:36","updated":"2025-06-06 19:37:36","focus_keyword":null,"additional_keywords":null,"truseo_locale":null,"seo_analyzer_scan_date":null},"aioseo_breadcrumb":"<div class=\"aioseo-breadcrumbs\"><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/ayurvedanetworkbhu.com\" title=\"Home\">Home<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/ayurvedanetworkbhu.com\/?cat=57\" title=\"Experts\">Experts<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\t<a href=\"https:\/\/ayurvedanetworkbhu.com\/?cat=113\" title=\"Dr. Prashant Kumar Gupta\">Dr. Prashant Kumar Gupta<\/a>\n\t\t<\/span><span class=\"aioseo-breadcrumb-separator\">&raquo;<\/span><span class=\"aioseo-breadcrumb\">\n\t\t\tModule on \u201cAyurveda and Drug Re-purposing\u201d by Dr. Prashant Gupta\n\t\t<\/span><\/div>","aioseo_breadcrumb_json":[{"label":"Home","link":"https:\/\/ayurvedanetworkbhu.com"},{"label":"Experts","link":"https:\/\/ayurvedanetworkbhu.com\/?cat=57"},{"label":"Dr. Prashant Kumar Gupta","link":"https:\/\/ayurvedanetworkbhu.com\/?cat=113"},{"label":"Module on &#8220;Ayurveda and Drug Re-purposing&#8221; by Dr. Prashant Gupta","link":"https:\/\/ayurvedanetworkbhu.com\/?p=2053"}],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=\/wp\/v2\/posts\/2053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2053"}],"version-history":[{"count":0,"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=\/wp\/v2\/posts\/2053\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=\/wp\/v2\/media\/3281"}],"wp:attachment":[{"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2053"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2053"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ayurvedanetworkbhu.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}