Adhyashan: A Key Factor in Insulin Resistance
Dr. Amit Nakanekar,
MD (Ayu.), Ph.D., Assistant Professor,
Department of Kaychikitsa, Government Ayurveda College, Nagpur
Insulin resistance is the phenomenon by which the cell inhibits the entry of insulin molecules inside the cell. This is responsible for defective insulin action. For many hormones in the body, the two types of the phenomenon are- resistance and assistance. Resistance will oppose the entry of a particular molecule inside the cell, while assistance will provide entry of molecule inside the cell by some receptor mechanism. Therefore, to understand this concept it is very important to know how insulin resistance can happen inside the body. Impairment of insulin signal transduction enzymes, proteins leads to insulin resistance. Insulin resistance at the level of hepatocytes increases blood glucose level which leads to decreased uptake of glucose at the adipose tissue level and skeletal muscle level. 
Ayurveda concept of digestion is nicely explained by Charaka in Grahanichikitsa Addhyaya. Agni (metabolic power) is Addhisthan (site) for digestion. Agni is situated in Grahani above the umbilicus. The function of Grahani is to hold the food till it gets digested and release this food after digestion. 
If the Agni is weak, indigested food moves in to forward direction without proper digestion. There are three types of defective eating, all these three types of defective eating can create diseases that are difficult to treat. These defective types of eating are Adhyashan, Vishamashan, and Samashan which means it is a mixture of a healthy and unhealthy diet. When healthy and unhealthy diet both are mixed together and eaten is called as Samashan. Pathya and Apathya diet mixed together causes diseases. Vishamashan means taking more or less food than the requirement, also taken at inappropriate timings. Food is taken at inappropriate timings that is before the feeling of hunger or not taking food in spite of it. Adhyashan means eating before the digestion of a meal, eating again in a very short time after the meals. 
Food consists of Six Rasas (Madhura-sweet, Amla-sour, Lavana,Katu , Tikta, Kashay). During digestion, food has to pass through the phases of digestion namely Madhur, Amla, and Katu Avasthapak. Every Rasa turns to be Madhur Rasa in the first AvasthaPak (Madhur avasthapak -1st stage of digestion) and it increases the Kapha. If food intake is done before the end of the first Avasthapak, the duration of Madhur Avasthapak will be prolonged.  If it continued like this, the whole body will be exposed to Madhurata (Sweetness-increased blood sugar level) for a longer duration. It will show the symptoms of Madhur Rasa Ati Yoga (symptoms of excessive intake of sweet). These are Sthaulya(obesity), Agnisad, Guruta(Heaviness in the body), Alasaka (excessive indigested food), Atinidra(excessive sleep), Shwas(Respiratory diseases), Prameha(Diabetes), Galroga(Throat diseases), Visangyata, Alasya, Galagand(Goitre), Arbuda(tumor), Gandamala(Thyroiditis), Udarda, Kasa(Cough), Krimi(worm infestation).
Diagnostic features of insulin resistance are hyperinsulinemia, hyperglycemia or normoglycemia, and anti-insulin antibodies. The effect of insulin resistance manifests on the heart, brain, kidney, blood vessels, and many more organs. 
Physiologically basal insulin secretion level is maintained at 10 μU /ml. It is secreted in two phases after meals. Phase 1 Active Phase or 1st phase of glucose-stimulated insulin secretion, influences fasting to feeding duration. In this phase, it works by inhibition of glucose production by hepatocytes, reduced lipolysis, decreased intake of glucose by adipose tissue.1st phase of insulin secretion is quick and 2nd phase is slow and gradually increasing. The second phase which is a passive phase of insulin secretion also inhibits glucose production by hepatocytes up to a lesser extent, but most importantly it increases the utilization of glucose by peripheral tissue. Graph 1 shows the phases of insulin secretion.
Graph 1: Phases of insulin secretion after a meal
Adhyashan includes eating before the digestion of a meal, eating again in a very short time after the meals. This means 1st phase of insulin secretion repeatedly occurs before the completion of the second phase of insulin secretion. This cycle goes on repeatedly causing insulin resistance. Graph 2 shows the effect of Adhyashan on insulin secretion phases. Adhyashan has some role in the development of insulin resistance and its mechanisms can be correlated with disturbance in phases of insulin secretion leading to insulin resistance.
Graph 2:Possible effect of Adhyashan on insulin secretion phases
1) अपक्वं धारत्यन्नं पक्वं सृजति पार्श्वतः|
(a) च.चि. १३
(b) च.चि १५
(c) च.चि १४
(d) च.चि १६
2) Basal level of insulin in the body is….
3) पथ्यापथ्यमिहैकत्र भुक्तं ….. मतम्||२३५||
4) Process of Digestion is described in which of the following chapter by Charak
5) First rise of insulin secretion peak occurs in what duration?
a) 0- 5 min
b) 5-10 min
c) 10-15 min
d) 15-20 min
6) अध्यशन may cause….
b) Insulin resistance
c) Both a and b
d) Neither a and b
7) Match the pairs
a) प्रथम अवस्था 1) कटु
b) द्वितीय अवस्था 2) मधुर
c) तृतिय अवस्था 3) अम्ल
A) a (1), b (2), c (3)
B) a (2), b (3), c (1)
C) a (3), b (1), c (2)
D) neither of above
8) Which of the following are signs of insulin resistance?
c) Anti-Insulin antibody
d) All of above
9) Match the pairs
(a) मधुर अवस्था १) आमशय
(b) अम्ल अवस्था २) ग्रहणी
(c) कटु अवस्था ३) पक्वाशय
A) a-1, b-2, c-3
B) a-2, b-3, c-1
C) a-3, b-1, c-2
D) neither of above
10) बहुभुक्तमल्पभुक्तं वा तथाऽप्राप्तमतीतकालं च भुक्तं ……मुच्यते|
- Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019). Insulin resistance: Review of the underlying molecular mechanisms. Journal of cellular physiology, 234(6), 8152–8161. https://doi.org/10.1002/jcp.27603
- Tripathi B., editor. Charak Samhita; Varanasi.1sted. Chikitsasthan, Grahani Chikitsa Addhyaya, chapter 15, verse 6, 57 Chaukhamba Surbharti Prakashan; 2013
- Sharma S., editor. Ashtang sangraha Samhita; Varanasi.1sted. Sutrasthan, Annapanviddhi adhyaya, chapter 10, verse 27 Chaukhamba Surbharti Series; 2016
- Tripathi B., editor. Charak Samhita; Varanasi.1sted. Chikitsasthan, Grahani Chikitsa Adhyay, chapter 15, verse 9, 10 Chaukhamba Surbharti Prakashan; 2013
- Tripathi B., editor. Charak Samhita; Varanasi.1sted. Sutrasthan, Aatreyabhadrakapyiaya Adhyaya, chapter 26, verse 41 Chaukhamba Surbharti Prakashan; 2013
- Di Pino A, DeFronzo RA. Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents. Endocr Rev. 2019; 40(6):1447-1467. doi:10.1210/er.2018-00141
- Park SY, Gautier JF, Chon S. Assessment of Insulin Secretion and Insulin Resistance in Human. Diabetes Metab J. 2021; 45(5):641-654. doi:10.4093/dmj.2021.0220